Introduction

The market for therapeutic antibodies has dramatically expanded over the past decades since their first approval in 1986.

Antibodies, which are proteins, form their structure and exert their activity through a complex series of non-covalent bonds and may lose their activity due to various external stimuli.

Therefore, the evaluation of structural stability is extremely important in the development and formulation of candidate antibodies.

Thermodynamic stability of antibodies is generally evaluated by DSC (differential scanning calorimetry) and circular dichroism (CD) spectroscopy.

Circular Dichroism spectroscopy is an easy and rapid method for obtaining information on the secondary and tertiary structure of proteins in solution and can be used to directly evaluate the protein structural change caused by heat.

Recently, Micsonai et al. developed the BeStSel algorithm that can accurately estimate the secondary structure composition from the CD spectrum by taking into account the parallel-antiparallel orientation of the β-strands and the twist of the antiparallel β-sheets.

BeStSel has the following features:

High estimation accuracy for a wide range of proteins, including β-structure-rich-proteins such as antibodies

Providing eight types of secondary structure information

A capability to predict the protein fold following the CATH classification

An open web server

While many academic researchers use the BeStSel web server, researchers in biopharma who need to work in a GxP environment have not been able to benefit from BeStSel.

To make BeStSel accessible to biopharma, JASCO developed Spectra Manager™ Ver.2.5 CFR BeStSel as an add-in software for Spectra Manager™, a control and analysis platform for CD spectrometers, which is compatible with GxP.

The Unhealer [portable] -

The story takes place in a distant future where humanity has colonized other planets. The protagonist, Zephyr, lives on a planet called Atheria, where magic and technology coexist. Zephyr is an UnHealer, someone with the rare ability to absorb and neutralize magical energies. This power makes them a valuable asset to the government, which seeks to control and exploit their gift.

The supporting cast includes a diverse range of characters, each with their own motivations and conflicts. These characters add depth and complexity to the narrative, which is driven by Zephyr's journey of self-discovery. The Unhealer

Throughout the novel, Tagg explores themes of identity, power, and social hierarchy. Zephyr's character development is a central focus of the story, as they grapple with the weight of their responsibilities and the secrets surrounding their past. The story takes place in a distant future

"The UnHealer" has received generally positive reviews from readers and critics. The novel has been praised for its unique world-building, engaging characters, and thought-provoking themes. Some reviewers have noted that the pacing can be slow at times, but overall, the book has been well-received by fans of science fiction and fantasy. This power makes them a valuable asset to

As Zephyr navigates their complex world, they begin to question their existence and the morality of their role in society. They are torn between their loyalty to the government and their growing desire for autonomy and freedom.

"The UnHealer" is a compelling and immersive novel that explores the complexities of power, identity, and social hierarchy. Sophie J. Tagg's writing is engaging, and her world-building is rich and detailed. If you're a fan of science fiction, fantasy, or are simply looking for a new series to follow, "The UnHealer" is definitely worth checking out.

"The UnHealer" is a science fiction novel written by Sophie J. Tagg, a British author. The book was published on June 17, 2021.